ea0005oc22 | Obesity and Diabetes | BES2003
Draper N
, Walker E
, Bujalska I
, Tomlinson J
, Chalder S
, Bedendo O
, Mason P
, Laing I
, Ray D
, Malunowicz E
, Connell J
, Hewison M
, Stewart P
11beta-Hydroxysteroid dehydrogenase (11beta-HSD) catalyses the interconversion of hormonally active cortisol (F) and inactive cortisone (E). 11beta-HSD1 is an NADP(H) dependent enzyme expressed in human liver and adipose that is targeted to the ER membrane with a lumenal catalytic domain. In vivo the enzyme acts predominantly as a reductase, generating F from E. The inherited condition, Apparent Cortisone Reductase Deficiency (ACRD) is a form of PCOS characterised by ACTH medi...